| ProductBackground:Hyaluronicacid(HA)isahighmolecularweightanionicpolysaccharide(1,000-10,000kD)composedofrepeatingdisaccharidesandisoneofseveralglycosaminoglycancomponentsoftheextracellularmatrixofconnectivetissue.FreeHAistakenupbytheliverwhereitisdegradedandrecycled.Manychronicliverdiseases,includinginfection(hepatitisBorC),toxicity(alcoholanddrugs),genetic(hemochromatosis),autoimmunity,andmalignancy,resultinliverinflammationwhichcanprogresstoliverfibrosisandcirrhosis;causingimpairmentofliverfunctionandresultinginarapidincreaseincirculatingHAlevels.
 DataindicatesarelationshipbetweenHAlevels,localinflammationandseverityofdisease.RecentpublicationshavealsoshownthatHAlevelsinurineareindicativeofbladdercancer,thatHAlevelsaredirectlycorrelatedtoliverdisease,andsuggestsenhancedbreakdownofHAinthelungsofpatientswithchronicobstructivepulmonarydisease.Inaddition,serumlevelsofHAhavebeenfoundtobeelevatedinpatientswithrheumatoidarthritis.
 
 FeaturedinPublications:(seetheHAELISATDSformorereferences)
 1.Meuwese,M.C.,H.L.Mooij,etal.(2009)."Partialrecoveryoftheendothelialglycocalyxuponrosuvastatintherapyinpatientswithheterozygousfamilialhypercholesterolemia."JLipidRes50(1):148-153.
 2.Vendrov,A.E.,N.R.Madamanchi,etal.(2010)."NADPHOxidasesRegulateCD44andHyaluronicAcidExpressioninThrombin-treatedVascularSmoothMuscleCellsandinAtherosclerosis."JournalofBiologicalChemistry285(34):26545-26557.
 3.B.KIM,etal.(2010)."Retinylretinoateinduceshyaluronanproductionandlessirritationthanotherretinoids."TheJournalofDermatology37(5):448-454.
 
 RelatedProducts:CollagenIVELISAKit(K-1700)
 
 ProductKeywords:Hyaluronan,Hyaluronate,LiverCirrhosis,RheumatoidArthritis,Hyaluronan,Osteoarthritis,LiverFibrosis
 
 
 
 
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