| Immunogen | Humanmelanomacellline. | 
| Clone | ME20.4 | 
| Host | Mouse | 
| Specificity | Reactswiththelowaffinitynervegrowthfactorreceptor(NGFRp75).Theepitoperecognizedbytheantibodymapswithinthethirdorfourthcysteine-richrepeatsoftheNGFRmolecule.Reactivityhasnotbeenobservedwithrat,chicken,ormouseNGFR. | 
| Isotype | IgG1 | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Nervegrowthfactorreceptorcontainsanextracellulardomaincontainingfour40-aminoacidrepeatswith6cysteineresiduesatconservedpositionsfollowedbyaserine/threonine-richregion,asingletransmembranedomain,anda155-aminoacidcytoplasmicdomain.Thecysteine-richregioncontainsthenervegrowthfactorbindingdomain. | 
| GeneSymbol | NGFRp75(NTR)TNFRSF16Gp80-LNGFRCD271
 | 
| Non-ReactiveSpecies |  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P08138#LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells. SIZE:427aminoacids;45183Da
 SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1.InteractswithBEX1andNGFRAP1/BEX3.
 SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
 DOMAIN:SwissProt:P08138DeathdomainisresponsIBLeforinteractionwithRANBP9.
 PTM:N-andO-glycosylated.&O-linkedglycansconsistofGal(1-3)GalNAccoreelongatedby1or2NeuNAc.&Phosphorylatedonserineresidues.
 SIMILARITY:Contains1deathdomain.&Contains4TNFR-Cysrepeats.
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