| Immunogen | Purifiedtyrosinehydroxylase(EC1.14.16.2)fromaratpheochromocytoma(2). | 
| Clone | 2/40/15 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | Tyrosinehydroxylase(TH)catalyzestherate-determininginitialstepinthebiosynthesisofcatecholaminessuchasdopamine,noradrenalineandadrenaline.Thereforetheantibodyisusedtostaindopaminergeousandadrenergeousneuronsaswellasthechromaffinetissueoftheadrenalmedulla.CelllinessuchasthePC12line,whichisderivedfromaratpheochromocytomaalso,showpositivereactions.Inimmunoblotsofadrenalmedullatissue,theantibodyrecognizesasingleproteinbandinthemolecularweightrangeof56-60kD. | 
| Isotype | IgG2a | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Tyrosinehydroxylaseisinvolvedintheconversionoftyrosinetodopamine.Astherate-limitingenzymeinthesynthesisofcatecholamines,tyrosinehydroxylasehasakeyroleinthephysiologyofadrenergicneurons. | 
| GeneSymbol |  | 
| PurificationMethod | ProteinAPurfied | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion.
 SIZE:528aminoacids;58524Da
 TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands.
 DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism.
 SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily.
 | 
| MolecularWeight | 56-60kDa |