| Immunogen | Ratswereimmunizedwithaglycoproteinfractionfromcerebellumof8-10dayoldC57BL/6Jmice. | 
| Clone | 324 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rat | 
| Specificity | MonoclonalantibodyagainstneuralcelladhesionmoleculeL1fromrat-rathybridcells. | 
| Isotype | IgG | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | ThisgeneisamemberoftheIgsuperfamilyandencodesacellsurfacesialoglycoproteinexpressedbycytokine-activatedendothelium.ThistypeImembraneproteinmediatesleukocyte-endothelialcelladhesionandsignaltransduction,andmayplayaroleinthedevelopmentofartherosclerosisandrheumatoidarthritis.Twoalternativelysplicedtranscriptsencodingdifferentisoformshavebeendescribedforthisgene. | 
| GeneSymbol | VCAM1INCAM-100MGC99561CD106DKFZp779G2333L1CAM
 | 
| PurificationMethod | ProteinAPurfied | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P19320#Importantincell-cellrecognition.Appearstofunctioninleukocyte-endothelialcelladhesion.Interactswiththebeta-1integrinVLA4onleukocytes,andmediatesbothadhesionandsignaltransduction.TheVCAM1/VLA4interactionmayplayapathophysiologicrolebothinimmuneresponsesandinleukocyteemigrationtositesofinflammation. SIZE:739aminoacids;81276Da
 SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
 TISSUESPECIFICITY:Expressedoninflamedvascularendothelium,aswellasonmacrophage-likeanddendriticcelltypesinbothnormalandinflamedtissue.
 DOMAIN:SwissProt:P19320EitherthefirstorthefourthIg-likeC2-typedomainisrequiredforVLA4-dependentcelladhesion.
 PTM:Sialoglycoprotein.
 DISEASE:SwissProt:P19320#Mayplayanimportantroleinthegenesisofatherosclerosisandrheumatoidarthritis.
 SIMILARITY:Contains7Ig-likeC2-type(immunoglobulin-like)domains.
 | 
| MolecularWeight | 120-140kDa |