| Ethanol(EtOH)hasmultipleeffectsonhumansandotheranimals.Alcoholaddictionandorgandamageareactiveareasofresearchwithaneedforresearchreagentsandtools.1Phosphatidylethanol(PEth)isadirectmetaboliteofEtOHandhasbeendescribedasalong-livedbioMarkerforalcoholingestion.2,3ItispossIBLethatPEthisinvolvedintheneurological4,protective5,andharmful6effectsofalcohol,butthemechanismsarestillbeingexplored.Autologousanti-PEthantibodiesarefoundinlowerabundanceinserumfromheavierdrinkers.Thisinverserelationshipbetweenanti-PEthIgGlevelsandalcoholingestionwasfirstreported,byNissinenet.al.7EvaluationofserumsamplesofvaryingconsumptionhABItshasdemonstratedahighdegreeofcorrelationwithingestedalcohol.Measuringtheseautologousanti-PEthIgGlevelsmayserveasaneffectivebiomarkerinmonitoringalcoholuse.
 
 Storage4°CReferences1.Freeman,W.M.;Vrana,K.E.FutureProspectsforbiomarkersofalcoholconsumptionandalcohol-induceddisorders.AlcoholClinExpRes2010,34,946-54.2.Viel,G.;etal.Phosphatidylethanolinbloodasamarkerofchronicalcoholuse:asystematicreviewandmeta-analysis.IntJMolSci2012,13,14788-812.
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 5.Foster,D.A.;etal.Reducedmortalityandmoderatealcoholconsumption:thephospholipaseD-mTORconnection.CellCycle2010,9,1291-4.
 6.Pannequin,J.;atal.PhosphatidylethanolaccumulationpromotesintestinalhyperplasiabyinducingZONAB-mediatedcelldensityincreaseinresponsetochronicethanolexposure.MolCancerRes2007,5,1147-57.
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