| Productbackground:CollagenIVisamajorcomponentoftheextracellularmatrixandprovidesthemainstructuralsupportforthebasementmembrane.IthasbeendemonstratedthatavarietyofdiseasescausealterationsinCollagenIVsynthesis,degradationandreleaseatthetissuelevel.TheserumlevelofCollagenIVisalteredinseveraltypesofdiseases,includingliverfibrosis(agoodindexwithhyaluronicacid)andcirhosis.ResearchhasshownthatthelossofCollagenIVinthebasementmembrane(withaconcurrentincreaseinCollagenaseactivity)positivelycorrelateswiththeprogressionofcancer.CollagenIVintheseramaybeindicativeoftissueCollagenIVdegradationandmaycorrelatewithcancerprogression.
 Echelon'sCollagenIVELISAKitIIisaquantitativesandwichimmunoassydesignedforinvitromeasurementofcollagenIVlevelsinBIOLOGicalsamples.TheconcentrationofcollagenIVwiththesampleisdeterminedusingastandardcurveofknownamountsofcollagenIV.
 
 RelatedProducts:
 HyaluronanEnzyme-LinkedImmunosorbentAssay(K-1200)
 HyaluronicAcidSandwichELISA(K-4800)
 CollagenIVAssayService(T-1700)
 
 Keywords:Hyaluronan,Liverfibrosis,COL4A1,COL4A2,COL4A3,COL4A4,COL4A5,COL4A6
 
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