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Millipore/FCCH025142 | FlowCellect? Cell Cycle Checkpoint H2A.X DNA Damage Kit/FCCH025142/25 Tests / Kit
  • Millipore/FCCH025142 | FlowCellect? Cell Cycle Checkpoint H2A.X DNA Damage Kit/FCCH025142/25 Tests / Kit

Millipore/FCCH025142 | FlowCellect? Cell Cycle Checkpoint H2A.X DNA Damage Kit/FCCH025142/25 Tests / Kit

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貨號: FCCH025142
品牌: Millipore
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    • Description
      CatalogueNumberFCCH025142
      TradeName
      • FlowCellect
      DescriptionFlowCellect?CellCycleCheckpointH2A.XDNADamageKit
      OverviewMillipore’sFlowCellect?DNADamage(HistoneH2A.X)andCellCycleAnalysisKitisdesignedtoidentifythelinkagebetweenDNAdamageinrelationtocellcyclecheckpointsinflowcytometryapplications.ThekitincludesadirectlyconjugatedAnti-phospho-HistoneH2A.X(Ser139)AlexaFluor?488antibodyplusaDNAdye(PropidiumIodide)whichallowstheresearchertoperformbivariateanalysistoidentifywhereDNAdamagetakesplacerelativetothepositioningwithinthecellcycle.Thekitincludesanoptimizedprotocolwithallofthenecessarycomponentstoprovidetheresearcheratrue“plugandplay”designfortheirresearchwhenstudyingDNAdamageandcellcyclecheckpoints.Thisimmunocytochemicalmethodisverysensitive,anditoffersanassaytoscreenanti-tumordrugsateveryphaseofthecellcycle.

      Inall,acomprehensiveunderstandingofDNAdamageanditsassociationwithcellcyclebehaviorcanprovidetheresearcherwithusefulinformationwhichwillbeimportantininterpretingtheintrinsicnatureofcellproliferation,apoptosis,DNArepair,andassistinthedevelopmentofanti-neoplasticagents.Millipore’sFlowCellect?DNADamage(HistoneH2A.X)andCellCycleAnalysisKitisdesignedtoallowtheresearchertoeasilyidentify,discriminate,andquantitatecellsundergoingDNAdamagerelativetoitspositioningwithinthecellcycle.

      AllFlowCellectkitsareoptimizedonguava?benchtopflowcytometers.FlowCellectkitscanbeusedonanyflowcytometerfollowingthesameprotocolprovidingresearchersareliableandfullyvalidatedsolutiontostudyDSBsandcellcycledistributionrightinthecomfortoftheirownlab.Thiskitcontainsoptimizedfixation,permeABIlization,wash,andflowbufferstoprovideresearcherswithacompletesolutionforbivariateanalysistoassessDNAdamageinrelationtopositioningwithinthecellcycle.
      AlternateNames
      • FlowCellect
      BackgroundInformationDetectionofDNAdamageduetodoublestrandedbreaks(DSBs)isafundamentalmethodforassessingcellhealthandevaluationofanti-neoplasticagents.BivariateanalysismonitoringtheextentofH2A.XphosphorylationalongwithaDNAdyeoffersasensitiveandvaluabletoolinstudyingthefactorsthatinduceDNAdamage(measuredbythelevelofDSBs)and/oraffectDNArepair.UnderstandingwherethefirstindicationofDSBstakeplaceduringthecellcyclecanhelpresearchersunderstandthemechanismsinvolvedincellcyclearrestandDNArepairatcriticalcellcyclecheckpoints.MalfunctionsinthecellcycleinresponsetoDNAdamagecanincreasetheincidenceofcancersincetheDNArepairmachineryfailstooperateproperly.ThisisimportantbecausethecellhasseveralsystemsforinterruptingthecellcycleiftheDNArepairmachinerymalfunctions.EvidencesuggeststhatH2A.XphosphorylationmayrecruitcheckpointproteinstositesofDNAdamageandplayaroleinDNArepair.

      VariousfactorscancauseDNAdoublestrandedbreaksresultinginDNAdamage.PhysicalfactorssuchasUVandionizingrADIation,orchemicalfactorssuchassyntheticcompounds(anti-tumordrugs)canallcauseDNAdamage.RegardlessofthesourcetoinduceDNAdamage,theendresultwilleithercausecellcyclecheckpointarrest,apoptosis,orwilltriggertheDNArepairresponsetodamage.
      ProductInformation
      Components
      • 1.20XAnti-p-HistoneH2A.X(Ser139),cloneJBW301-AlexaFluor?488Conjugate:(PartNo.CS206387)Onevialcontaining150μLantibody.
      • 2.PropidiumIodideSolution:(PartNo.CS204836)Onevialcontaining400μLDNAdye.
      • 3.RNaseAReagent:(PartNo.CS204821)Onevialcontaining25μL.
      • 4.FixationBuffer:(PartNo.CS202122)Onebottlecontaining13mLbuffer.
      • 5.10XWashBuffer:(PartNo.CS202123)Onebottlecontaining13mLbuffer.
      • 6.5XAssayBuffer:(PartNo.CS202124)Onebottlecontaining55mLbuffer.
      • 7.1XPermeabilizationBuffer:(PartNo.CS203284)Twobottlescontaining14mLbuffer.
      DetectionmethodFluorescent
      StorageandShippingInformation
      StorageConditions4-8°Cforantibodiesandbuffers
      Applications
      ApplicationThisFlowCellectDNADamage(HistoneH2A.X)&CellCycleAnalysisKitforFlowCytometryisdesignedtoidentifythelinkagebetweenDNAdamageinrelationtocellcyclecheckpointsinflowcytometryapplications.
      KeyApplications
      • FlowCytometry
      BIOLOGicalInformation
      CloneJBW301
      HostMouse
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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