| UniProtSummary | FUNCTION:Mayfunctionasatranscriptionfactor. SIZE:464aminoacids;49561Da
 SUBUNIT:EfficientDNAbindingrequiresdimerizationwithanotherbHLHprotein.BindsDNAasanheterodimerwithMAX.InteractswithKDM5A,KDM5BandHUWE1.
 SUBCELLULARLOCATION:Nucleus.
 DEVELOPMENTALSTAGE:Expressedduringfetaldevelopment.
 DISEASE:AmplificationoftheN-MYCgeneisassociatedwithavarietyofhumantumors,mostfrequentlyneuroblastoma,wherethelevelofamplificationappearstoincreaseasthetumorprogresses.
 DefectsinMYCNarethecauseofFeingoldsyndrome;alsoknownasoculodigitoesophagoduodenalsyndrome(ODED).Feingoldsyndromeischaracterizedbyvariablecombinationsofesophagealandduodenalatresias,microcephaly,learningdisABIlityandlimbmalformations.Cardiacandrenalmalformations,vertebralanomalies,anddeafnesshavealsobeendescribed.
 DefectsinMYCNarethecauseofmicrocephalyanddigitalabnormalitieswithnormalintelligence.
 SIMILARITY:Contains1basichelix-loop-helix(bHLH)domain.
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