| Immunogen | PurifiedhumanTcells | 
| Clone | UCHT1 | 
| Host | Mouse | 
| Specificity | Thisantibodyrecognizes22/26/30kDamolecularweightlymphocytesurfacemoleculesassociatedwiththeTcellantigenreceptorcomplex.CD3iscloselyassociatedonthelymphocytecellsurfacewiththeTcellantigenreceptorTcR(2-4).ItisbelievedthattheCD3complextransmitsactivationalsignalstotheTcell"sinterioruponantigenrecognitionbyTcR.CD45(LCA),aproteintyrosinephosphatase,isapotentregulatorofsignaltransductionbytheCD3complex.ItreactswiththemajorityofperipheralbloodTlymphocytes,amajorproportionofthymocytes,themajorityofTcellchroniclymphocyticleukaemiacells,Sézaryleukaemiasandapproximately70%ofacutelymphoblasticleukaemiasofTcellorigin. Antigendistribution:
 Tcells100%
 PeripheralBloodlymphocytes75+7%
 Thymocytes68+5%
 Granulocytes<>
 Monocytes<>
 Bcells(E-)<>
 NKcells(CD16+)<>
 KNOWNSPECIESCROSSREACTIVITY:Negativewithrhesusmonkeyperipheralbloodleucocytesinflowcytometry
 FUSIONPARTNER:P3x63Ag8.653myelomacellline
 | 
| Isotype | IgG1 | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | TheproteinencodedbythisgeneistheCD3-epsilonpolypeptide,whichtogetherwithCD3-gamma,-deltaand-zeta,andtheT-cellreceptoralpha/betaandgamma/deltaheterodimers,formstheT-cellreceptor-CD3complex.Thiscomplexplaysanimportantroleincouplingantigenrecognitiontoseveralintracellularsignal-transductionpathways.Thegenesencodingtheepsilon,gammaanddeltapolypeptidesarelocatedinthesameclusteronchromosome11.TheepsilonpolypeptideplaysanessentialroleinT-celldevelopment.Defectsinthisgenecauseimmunodeficiency.ThisgenehasalsobeenlinkedtoasusceptibilitytotypeIdiabetesinwomen. | 
| GeneSymbol |  | 
| Non-ReactiveSpecies |  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P07766#TheCD3complexmediatessignaltransduction. SIZE:207aminoacids;23147Da
 SUBUNIT:TheTCR/CD3complexofT-lymphocytesconsistsofeitheraTCRalpha/betaorTCRgamma/deltaheterodimercoexpressedatthecellsurfacewiththeinvariantsubunitsofCD3labeledgamma,delta,epsilon,zeta,andeta.
 SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
 SIMILARITY:SwissProt:P07766##Contains1Ig-like(immunoglobulin-like)domain.&Contains1ITAMdomain.
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