| Immunogen | GSTfusionproteincorrespondingtoacytoplasmic,N-terminalpartofratormouseVAMP-2(AccessionnumbersQ64357,NP036795). |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesVAMP-2(Vesicle-AssociatedMembraneProtein2,Synaptobrevin2).Theepitopedoesnotsharehomologywithanyotherknownproteins.
SPECIESREACTIVITIES:Itisexpectedthattheantibodywillalsoreactwithhuman,Macacamultataandbovineduetosequencehomology(25/26).Otherspecieshavenotbeentested. |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthevesicle-associatedmembraneprotein(VAMP)/synaptobrevinfamily.Synaptobrevins/VAMPs,syntaxins,andthe25-kDsynaptosomal-associatedproteinSNAP25arethemaincomponentsofaproteincomplexinvolvedinthedockingand/orfusionofsynapticvesicleswiththepresynapticmembrane.Thisgeneisthoughttoparticipateinneurotransmitterreleaseatastepbetweendockingandfusion.Theproteinformsastablecomplexwithsyntaxin,synaptosomal-associatedprotein,25kD,andsynaptotagmin.Italsoformsadistinctcomplexwithsynaptophysin.Itisalikelycandidategeneforfamilialinfantilemyasthenia(FIMG)becauseofitsmaplocationandbecauseitencodesasynapticvesicleproteinofthetypethathasbeenimplicatedinthepathogenesisofFIMG. |
| GeneSymbol | - VAMP2
- VAMP-2
- FLJ11460
- Synaptobrevin-2
- SYB2
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P63027#Involvedinthetargetingand/orfusionoftransportvesiclestotheirtargetmembrane. SIZE:116aminoacids;12649Da SUBUNIT:InteractswithVAPAandVAPB. SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane;Single-passtypeIVmembraneprotein.Note=Neuronalsynapticvesicles. TISSUESPECIFICITY:Nervoussystemandskeletalmuscle. SIMILARITY:SwissProt:P63027##Belongstothesynaptobrevinfamily.&Contains1v-SNAREcoiled-coilhomologydomain. |