| Immunogen | Fulllengthrecombinantratalpha-internexinfusedtoE.coliTrpE. | 
| Host | Rabbit | 
| Specificity | alpha-internexin,C-terminalglobular"tail"region.Bywesternblot,AB5354detectsamajorbandat66kDaandaminorbandatapproximately150kDacorrespondingtoalphainternexinmonomeranddimer,respectively.Aminorbandatapproximately50kDaisoccasionallydetectedandisbelievedtobeadegradationproductofalphainternexin.ThisantibodyhasbeenreferredtointheliteratureastheR36antibody(Evans,2002). | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| GeneSymbol | - INA
 - NF-66
 - NEF5
 - MGC12702
 - Alpha-Inx
 - TXBP-1
 - Neurofilament-66
 - Alpha-internexin
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:Q16352#Class-IVneuronalintermediatefilamentthatisabletoself-assemble.Itisinvolvedinthemorphogenesisofneurons.ItmayformanindependentstructuralnetworkwithouttheinvolvementofotherneurofilamentsoritmaycooperatewithNF-LtoformthefilamentousbackbonetowhichNF-MandNF-Hattachtoformthecross-bridges. SIZE:499aminoacids;55391Da TISSUESPECIFICITY:FoundpredominantlyinadultCNS. DEVELOPMENTALSTAGE:Expressedinbrainasearlyasthe16thweekofgestation,andincreasedrapidlyandreachedasteadystatelevelbythe18thweekofgestation. PTM:O-glycosylated(Bysimilarity).&PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:SwissProt:Q16352##Belongstotheintermediatefilamentfamily. |