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當(dāng)前位置： Millipore >>> Millipore/AB1955 | Anti-VE-Cadherin Antibody, phospho-specific [Tyr658]/AB1955/100 µL

Millipore/AB1955 | Anti-VE-Cadherin Antibody, phospho-specific [Tyr658]/AB1955/100 µL

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貨號: AB1955

品牌: Millipore

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Description
CatalogueNumber	AB1955
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-VE-CadherinAntibody,phospho-specific[Tyr658]
BackgroundInformation	VE-cadherinisanendothelialspecificadhesionmoleculethatisessentialforthemaintenanceofendothelialbarrierfunctionandangiogenesis.ItislinkedtotheactinCytoskeletonthroughanumberofadaptorproteinsincludingalpha,beta,andgammacatenin.CytoskeletaldynamicsandphosphorylationregulateVE-cadherinmediatedcellcelladhesion.Theinteractionbetweencytosolicc-terminalSrckinase,SH2domainandphosphorylatedtyrosine658siteofVE-Cadherinregulatesdensitydependentcellproliferation.Phosphorylationoftyrosine658hasbeenshowntoleadtouncouplingofp120-cateninfromthecytoplasmictailofVE-cadherin.Thisphosphorylationeventissufficienttomaintaincellsinamesenchymalstateduringthecellinvasionphaseofangiogenesis.

ProductInformation
Format	AffinityPurified
Presentation	Antibodyispurifiedfromrabbitserum.Itiscross-adsorbedtononphospho-peptidecorrespondingtothesiteofphosphorylationthenaffinitypurifiedusingphosphorylatedVEcadherin(Tyr658)peptide.Antibodyissuppliedin100μlphosphate-bufferedsaline(noCa²⁺,noMg²⁺),pH7.3,50%glycerol,containing1mg/mlBSA,and0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Maintainat-20°Cforuptooneyearor2°-8°Cforshorttermstoragefromdateofreceipt. Avoidrepeatedfreeze/thawcycles.

Applications
Application	Anti-VE-CadherinAntibody,phospho-specific[Tyr658]detectslevelofVE-Cadherin&hasbeenpublished&validatedforuseinWB.
KeyApplications	WesternBlotting

BIOLOGicalInformation
Immunogen	PhosphorylatedVE-cadherin(Tyr658)syntheticpeptidecorrespondingtohumanaminoacidresiduesaroundtyrosine658.Thesequenceisconservedinmouse,rat,porcine,bovine,canine,chickenandchimpanzee.
Host	Rabbit
Specificity	Theantibodydetectsa120kDaproteinofVE-cadherin.
SpeciesReactivity	Human
SpeciesReactivityNote	Thissequenceis100%homologousinmouse,rat,chicken,chimpanzee,cow,dogandpigVE-cadherin.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_001795.2
EntrezGeneSummary	Thisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.FunctioningasaclassiccadherinbyimpartingtocellstheABIlitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined.
GeneSymbol	CDH5 VE-cadherin CD144 7B4
Modifications	Phosphorylation
UniProtNumber	P33151
UniProtSummary	FUNCTION:SwissProt:P33151#Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton. SIZE:784aminoacids;87516Da SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein(Probable).Note=Foundatcell-cellboundariesandprobablyatcell-matrixboundaries. TISSUESPECIFICITY:Endothelialtissuesandbrain. SIMILARITY:SwissProt:P33151##Contains5cadherindomains.

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