Immunogen | Syntheticpeptidefromrat. |
Host | Rabbit |
Specificity | OligodendrocyteMarkerOlig2.ByWesternblottheantibodyrecognizesabandat~32kDainratbrainextract. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesabasichelix-loop-helixtranscriptionfactorwhichisexpressedinoligodendroglialtumorsofthebrain.TheproteinisanessentialregulatorofventralneuroectodermalProgenitorcellfate.Thegeneisinvolvedinachromosomaltranslocationt(14;21)(q11.2;q22)associatedwithT-cellacutelymphoblasticleukemia.Itschromosomallocationiswithinaregionofchromosome21whichhasbeensuggestedtoplayaroleinlearningdeficitsassociatedwithDownsyndrome. |
GeneSymbol | - OLIG2
- bHLHB1
- RACK17
- OLIGO2
- BHLHB1
- PRKCBP2
- Oligo2
|
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q13516#Requiredforoligodendrocyteandmotorneuronspecificationinthespinalcord,aswellasforthedevelopmentofsomaticmotorneuronsinthehindbrain.CooperateswithOLIG1toestablishthepMNdomainoftheembryonicneuraltube.AntagoNISTofV2interneuronandofNKX2-2-inducedV3interneurondevelopment(Bysimilarity). SIZE:323aminoacids;32385Da SUBUNIT:InteractswithNKX2-2(Bysimilarity). SUBCELLULARLOCATION:Nucleus(Bysimilarity).Cytoplasm(Bysimilarity).Note=TheNLScontainedinthebHLHdomaincouldbemaskedinthenativeformandtranslocationtothenucleuscouldbemediatedbyinteractioneitherwithclassEbHLHpartnerproteinorwithNKX2-2(Bysimilarity). TISSUESPECIFICITY:Expressedinthebrain,inoligodendrocytes.Stronglyexpressedinoligodendrogliomas,whileexpressionisweaktomoderateinastrocytomas.Expressioninglioblastomashighlyvariable. DOMAIN:SwissProt:Q13516ThebHLHisessentialforinteractionwithNKX2-2(Bysimilarity).DISEASE:SwissProt:Q13516#AchromosomalaberrationinvolvingOLIG2maybeacauseofaformofT-cellacutelymphoblasticleukemia(T-ALL).Translocationt(14;21)(q11.2;q22)withTCRA. SIMILARITY:Contains1basichelix-loop-helix(bHLH)domain. |