| Immunogen | Syntheticpeptide. | 
| Host | Rabbit | 
| Specificity | EphrinReceptorB2.ByWesternblottheantibodyrecognizesadoubletbandat~90-118kDainadultratbrainlysate. | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Ephrinreceptorsandtheirligands,theephrins,mediatenumerousdevelopmentalprocesses,particularlyinthenervoussystem.Basedontheirstructuresandsequencerelationships,ephrinsaredividedintotheephrin-A(EFNA)class,whichareanchoredtothemembranebyaglycosylphosphatidylinositollinkage,andtheephrin-B(EFNB)class,whicharetransmembraneproteins.TheEphfamilyofreceptorsaredividedinto2groupsbasedonthesimilarityoftheirextracellulardomainsequencesandtheiraffinitiesforbindingephrin-Aandephrin-Bligands.Ephrinreceptorsmakeupthelargestsubgroupofthereceptortyrosinekinase(RTK)family.Theproteinencodedbythisgeneisareceptorforephrin-Bfamilymembers. | 
| GeneSymbol | EPHB2EphB2CAPBEPHT3Hek5DRTEPTH3TYRO5ERKHEK5MGC87492PCBCTyro5
 | 
| PurificationMethod | ImmunoAffinityPurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P29323#Receptorformembersoftheephrin-Bfamily.Actsasatumorsuppressor. SIZE:1055aminoacids;117493Da
 SUBUNIT:Theligand-activatedforminteractswithmultipleproteins,includingGTPase-activatingprotein(RASGAP)throughitsSH2domain.BindsRASGAPthroughthejuxtamembranetyrosinesresidues.InteractswithPRKCABPandGRIP1(Bysimilarity).
 SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
 TISSUESPECIFICITY:Brain,heart,lung,kidney,placenta,pancreas,liverandskeletalmuscle.Preferentiallyexpressedinfetalbrain.
 DISEASE:SwissProt:P29323#DefectsinEPHB2areinvolvedintheprogressionofprostatecancer[MIM:176807].&DefectsinEPHB2areinvolvedinthedevelopmentofprostatecancermetastasistothebrain[MIM:603688].
 SIMILARITY:SwissProt:P29323##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Ephrinreceptorsubfamily.&Contains2fibronectintype-IIIdomains.&Contains1proteinkinasedomain.&Contains1SAM(sterilealphamotif)domain.
 | 
| MolecularWeight | ~90-118kDa |