| Host | Rabbit | 
| SpeciesReactivity | - Human
 - Mouse
 - Rat
 - Bovine
 - Pig
 - Rabbit
 - Yeast(S.cerevisiae)
 
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| EntrezGeneNumber |  | 
| EntrezGeneSummary | HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6. | 
| GeneSymbol | - HIST1H4A
 - H4/J
 - HIST1H4F
 - HIST1H4L
 - H4FN
 - H4FA
 - H4FH
 - HIST1H4H
 - H4F2
 - H4FM
 - H4/A
 - H4FK
 - H4FG
 - HIST2H4
 - H4FB
 - H4/K
 - HIST1H4I
 - H4/N
 - HIST1H4B
 - H4FE
 - H4/M
 - H4/a
 - HIST1H4E
 - HIST4H4
 - HIST2H4A
 - H4FC
 - H4FI
 - H4/H
 - HIST1H4C
 - H4/G
 - HIST1H4K
 - H4FJ
 - H4FD
 - H4/I
 - H4/B
 - H4/D
 - H4/C
 - HIST1H4J
 - HIST1H4D
 - H4/E
 
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| Modifications |  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SIZE:103aminoacids;11367Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins. SIMILARITY:SwissProt:P62805##BelongstothehistoneH4family. |