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Millipore/05-636 | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301/05-636/200 µg
  • Millipore/05-636 | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301/05-636/200 µg

Millipore/05-636 | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301/05-636/200 µg

價格: ￥5796.00 市場價: 9660.00
貨號: 05-636
品牌: Millipore
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    • Description
      CatalogueNumber05-636
      ReplacesMABE205
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-phospho-HistoneH2A.X(Ser139)Antibody,cloneJBW301
      AlternateNames
      • H2AXS139P
      • HistoneH2A.X(phosphoS139)
      BackgroundInformationHistoneH2Aisoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH2Aisinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.
      ProductInformation
      FormatPurified
      Control
      • UV-treated293cellextracts,UV-treatedHeLacellextractsorbreastcancertissue
      PresentationImmunoaffinityPurifiedimmunoglobulinin0.1MTris-Glycine,pH7.4,0.15MNaCl,0.05%sodiumazideasapreservative.
      StorageandShippingInformation
      StorageConditionsMaintainfor1yearat2to8°Cfromdateofshipment.Formaximumrecoveryofproduct,centrifugetheoriginalvialpriortoremovingthecap.
      Applications
      ApplicationAnti-phospho-HistoneH2A.X(Ser139),cloneJBW301isawellpublishedMouseMonoclonalAntibodyvalidatedinChIP,ICC,IF,WB.ThispurifiedmAbishighlyspecificforphospho-HistoneH2A.X(Ser139)alsoknownasH2AXS139p.
      KeyApplications
      • Immunocytochemistry
      • Immunofluorescence
      • WesternBlotting
      • ChromatinImmunoprecipitation(ChIP)
      ApplicationNotesAdditionalReferencedApplications:
      ChromatinImmunoprecipitation,seeMeier,Andreas,etal.EMBOJ.,26:2707-18(2007)intechnicalinformationtab.
      BIOLOGicalInformation
      Immunogenpeptide(C-KATQA[pS]QEY)correspondingtoaminoacids134-142ofhumanhistoneH2A.X
      CloneJBW301
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityRecognizesHistoneH2A.XphosphorylatedatSer139.
      IsotypeIgG1
      SpeciesReactivity
      • Vertebrates
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneencodesamemberofthehistoneH2Afamily,andgeneratestwotranscriptsthroughtheuseoftheconservedstem-loopterminationmotif,andthepolyAadditionmotif.
      GeneSymbol
      • H2AFX
      • H2AX
      • H2a/x
      • H2A/X
      • H2A.X
      Modifications
      • Phosphorylation
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P16104#VarianthistoneH2AwhichreplacesconventionalH2Ainasubsetofnucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Requiredforcheckpoint-mediatedarrestofcellcycleprogressioninresponsetolowdosesofionizingrADIationandforefficientrepairofDNAdoublestrandbreaks(DSBs)specificallywhenmodifiedbyC-terminalphosphorylation.
      SIZE:143aminoacids;15145Da
      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.InteractswithnumerousproteinsrequiredforDNAdamagesignalingandrepairwhenphosphorylatedonSer-140.TheseincludeMDC1,TP53BP1,BRCA1andtheMRNcomplex,composedofMRE11A,RAD50,andNBN.InteractionwiththeMRNcomplexismediatedatleastinpartbyNBN.AlsointeractswithDHX9/NDHIIwhenphosphorylatedonSer-140.
      SUBCELLULARLOCATION:Nucleus.DEVELOPMENTALSTAGE:SynthesizedinG1aswellasinS-phase.
      DOMAIN:SwissProt:P16104The[ST]-QmotifconstitutesarecognitionsequenceforkinasesfromthePI3/PI4-kinasefamily.
      PTM:PhosphorylatedonSer-140(toformgamma-H2AFX)inresponsetoDNAdoublestrandbreaks(DSBs)generatedbyexogenousgenotoxicagentsandbystalledreplicationforks,andmayalsooccurduringmeioticrecombinationeventsandimmunoglobulinclassswitchinginlymphocytes.PhosphorylationcanextenduptoseveralthousandnucleosomesfromtheactualsiteoftheDSBandmaymarkthesurroundingchromatinforrecruitmentofproteinsrequiredforDNAdamagesignalingandrepair.Widespreadphosphorylationmayalsoservetoamplifythedamagesignaloraidrepairofpersistentlesions.PhosphorylationofSer-140inresponsetoionizingradiationismediatedbybothATMandPRKDCwhiledefectsinDNAreplicationinduceSer-140phosphorylationsubsequenttoactivationofATRandPRKDC.DephosphorylationofSer-140byPP2AisrequiredforDNADSBrepair.Inmeiosis,Ser-140phosphorylationmayoccuratsynaptonemalcomplexesduringleptoteneasanATM-dependentresponsetotheformationofprogrammedDSBsbySPO11.Ser-140phosphorylationmaysubsequentlyoccursatunsynapsedregionsofbothautosomesandtheXYbivalentduringzygotene,downstreamofATRandBRCA1activation.Ser-140phosphorylationmayalsoberequiredfortranscriptionalrepressionofunsynapsedchromatinandmeioticsexchromosomeinactivation(MSCI),wherebytheXandYchromosomescondenseinpachytenetoformtheheterochromaticXY-body.Duringimmunoglobulinclassswitchrecombinationinlymphocytes,Ser-140phosphorylationmayoccuratsitesofDNA-recombinationsubsequenttoactivationoftheactivation-inducedcytidinedeaminaseAICDA.&MonoubiquitinationofLys-120byRING1andRNF2/RING2complexgivesaspecifictagforepigenetictranscriptionalrepression(Bysimilarity).
      SIMILARITY:BelongstothehistoneH2Afamily.
      MolecularWeight17kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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