| Immunogen | SyntheticpeptidecorrespondingtoresiduesinthetaildomainofhumanNeurofilament-66. | 
| Epitope | TailDomain | 
| Clone | EP676Y | 
| Host | Rabbit | 
| Specificity | ThisantibodyrecognizesNeurofilament-66atandaroundthetaildomain. | 
| Isotype | IgG | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | NeurofilamentsaretypeIVintermediatefilamentheteropolymerscomposedoflight,medium,andheavychains.Neurofilamentscomprisetheaxoskeletonandtheyfunctionallymaintaintheneuronalcaliber.Theymayalsoplayaroleinintracellulartransporttoaxonsanddendrites.Thisgeneisamemberoftheintermediatefilamentfamilyandisinvolvedinthemorphogenesisofneurons. | 
| GeneSymbol | Alpha-InxFLJ18662FLJ57501MGC12702NEF5NF-66Neurofilament-66OTTHUMP00000020403TXBP-1
 | 
| PurificationMethod | Unpurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:Class-IVneuronalintermediatefilamentthatisabletoself-assemble.Itisinvolvedinthemorphogenesisofneurons.ItmayformanindependentstructuralnetworkwithouttheinvolvementofotherneurofilamentsoritmaycooperatewithNF-LtoformthefilamentousbackbonetowhichNF-MandNF-Hattachtoformthecross-bridges. TISSUESPECIFICITY:FoundpredominantlyinadultCNS.
 DEVELOPMENTALSTAGE:Expressedinbrainasearlyasthe16thweekofgestation,andincreasedrapidlyandreachedasteadystatelevelbythe18thweekofgestation.
 PTM:O-glycosylatedBysimilarity.
 PhosphorylateduponDNAdamage,probablybyATMorATR.
 SEQUENCESIMILARITIES:Belongstotheintermediatefilamentfamily.
 | 
| MolecularWeight | ~66kDa |